Posted on 11-26-2013
PRENATAL EXPOSURE OF THIS COULD LEAD TO AUTISM
An urgent article from the May 9, 2013 issue of Environmental health finds yet another set of research that links acetaminophen (Tylenol) to autism!
KEY POINTS FROM THIS STUDY
Using the U.S. Centers for Disease Control and Prevention Summary of Autism/ASD Prevalence Studies database and all available country-level data (n = 8) for the period 1984 to 2005, these authors analyzed correlations between autism prevalence and exposure to acetaminophen in utero, and in early life, and as related to circumcision rates.
1) “The synchronous rises in autism/ASD prevalence and paracetamol (acetaminophen) use, as well as biologic plausibility have led to the hypothesis that paracetamol exposure may increase autism/ASD risk.”
2) There is substantial evidence implicating oxidative stress, inflammation and immune dysregulation as being linked to autism.
3) Medication use, especially paracetamol (acetaminophen) in pregnancy and early childhood may play a role in ASD etiology.
4) Acetaminophen is one of the most common antipyretic analgesic medicines worldwide.
5) In 1980, the association between aspirin and Reyes syndrome, moved acetaminophen essentially to the primary treatment of fever in children and pregnant women. This has dramatically increased consumption of acetaminophen throughout the world.
6) In 1982 and again in 1986, Tylenol product tampering caused a rapid and brief decline in sales with paralleling brief dips in the rising autism prevalence curves.
7) Prior to the 1990’s circumcision was generally performed without analgesics. However, circumcision pain management guidelines by the American Academy of Pediatrics include the suggestion of a first dose of acetaminophen two hours prior to the procedure, and doses every 4–6 hours for 24 hours following the procedure. “Thus newborn males often receive 5–7 doses of acetaminophen during the developmentally vulnerable initial days of life.” Males have 4.6 times higher prevalence of autism compared to females.
8) In 1980, US acetaminophen sales were by $2.6 billion.
9) In the 8 countries analyzed in this study, acetaminophen consumption was correlated with autism/ASD prevalence. This includes prenatal exposure and early life exposure.
10) “These ecological analyses identified positive correlations between autism/ASD prevalence and indicators of both prenatal and very early life [acetaminophen] exposures.”
11) “The use of [acetaminophen] during pregnancy and at the time of circumcision may help to explain autism/ASD prevalence variations between the sexes.”
12) “Previous research has identified [acetaminophen] usage trends that curiously coincide with the rise in prevalence and population demographics of autism/ASD.”
13) In the early 1980’s about 42% of women used acetaminophen during the first trimester of pregnancy. The rate is now over 65%.
14) Maternal viral and bacterial infections increase the risk of autism. This can be explained by maternal consumption of acetaminophen for the symptoms associated with these infections.
15) In the US, “usage of paracetamol [acetaminophen] by pregnant women mirrors the population demographics of women whose children develop autism spectrum disorder, by race, age and education.”
16) “[Acetaminophen] is the most common drug administered to US children and the predominant analgesic/antipyretic drug among children up to 24 months of age.”
17) “[Acetaminophen] is suggested for pain management following vaccinations.” “In 1983 the average U.S. child received 8 immunizations before age 2. In 2011, the average was 25, a 313% increase.”
18) Acetaminophen treatment induces greater glutathione depletion.
19) In this analysis, “a correlation was found between maternal prenatal use of [acetaminophen] and autism spectrum disorder.”
20) “A correlation was identified for the first time between neonatal circumcision with a probable [acetaminophen] exposure and autism spectrum disorder,” giving a plausible cause for the increased male rates of autism.
This is our 5th article on this topic, acetaminophen causing autism: scary.
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The first prospective cohort study has been published to look at children exposed to long-term use of acetaminophen during pregnancy and has found they had substantial adverse developmental outcomes at 3 years of age. These developmental outcomes are typical autism phenotypes. Exposure to acetaminophen for more than 28 days in pregnancy increases risk of psychomotor and behavioral outcomes by almost 70% and doubles the risk of language problems. No association of adverse neurodevelopment was found with ibuprofen suggesting a specific effect of acetaminophen that is less likely to be confounded by indication. http://www.ncbi.nlm.nih.gov/pubmed/24163279 http://sciencenordic.com/prenatal-use-paracetamol-linked-kids%E2%80%99-problems