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Posted on 11-18-2011

Morning Redding!

Here's a great study I came across to help explain allergies. Here is the study:

The Importance of Prenatal Exposures on the Development of Allergic Disease A Birth Cohort Study

American Journal Of Respiratory And Critical Care Medicine Vol. 166, pp. 827-832, 2002

Tricia M. McKeever, Sarah A. Lewis, Chris Smith, and Richard Hubbard FROM ABSTRACT:

The etiology of allergic disease is not understood, but a decreased exposure to infection may play an important role.

There are few published data on the impact of change in microbial exposure during pregnancy on the child's risk of developing allergic disease.

Using a birth cohort of 24,690 children, we investigated a number of perinatal exposures on the incidence of asthma, eczema, and hay fever.

Our findings suggest that exposure to antibiotics in utero is associated with an increased risk of asthma in a dose-related manner (more than two courses of antibiotics) compared with none, and similar associations are present for eczema and hay fever.

Our findings suggest that exposure to antibiotics in utero is a potentially important risk factor in the development of allergic disease.

THESE AUTHORS ALSO NOTE:

"The prevalence of allergic disease has increased dramatically in the developed world during the second half of the 20th century, and it has been suggested that this increase is in part due to reductions in early microbial exposure."

"The main evidence for this hypothesis comes from research demonstrating strong protective birth order effects on the risk of having or developing an allergic disease (8 references) and also that exposure to antibiotics early in life increases the risk of developing allergic disease (5 references)."

"Because the immune system develops in utero, factors that modify microbial exposure at this time may have a long-term impact on the risk of developing allergic disease."

"Approximately one third of the mothers were prescribed one or more courses of antibiotics during pregnancy, and this exposure was associated with an increased incidence of all three allergic diseases."

"This effect did not appear to depend on the type of antibiotic prescribed or the trimester the antibiotics were prescribed," "but there was some evidence of a dose-response effect, especially for asthma."

These authors have previously demonstrated an "increase in the risk of allergic disease

in children if they are exposed to antibiotics in the first year of life."
(McKeever TM, Lewis SA, Smith C, Collins J, Heatlie H, Frischer M, Hubbard R. Early exposure to infections and antibiotics and the incidence of allergic disease.
J Allergy Clin Immunol 2002; 109:43-50).

"There was no relationship between the use of antibiotics in the father during the pregnancy period and the incidence disease in the child."

"A diagnosis or treatment for depression in the mother was associated with an increased risk of developing all three allergic diseases."
[Could this be related to omega-3 essential fatty acid deficiency? We currently recommend 2,750mg/day for most individuals.  There is a strong correlation between systemic inflammation and allergies/depression.  Omega 3's destroy inflammation!]

DISCUSSION

"Our results suggest that exposure to antibiotics in utero is associated with a dose- related increase in the child's risk of allergic disease."

"Perinatal maternal depression was associated with an increased risk of having a diagnosis of all three allergic diseases, particularly asthma."
[Could this again, be related to omega-3 essential fatty acid deficiency?]

"Antibiotics can cross the placenta and enter the fetal circulation, and there are data that suggests that exposure to antibiotics early in life may increase the child's risk of developing allergic disease."

"We found a dose-response relationship between antibiotics given during pregnancy and the child's risk of developing an allergic disease, and to our knowledge, this is the first time that this association has been reported."

"The presence of older siblings has consistently been shown to decrease the incidence of allergic disease."

"A number of studies have found evidence of a relationship between atopic disease and affective disorders (7 references)."
[Again, could this be related to omega-3 essential fatty acid deficiency?]

"Our results suggested that maternal depression may increase the incidence of the child's allergic diseases, particularly asthma."

"Parental stress early in life increases the child's risk of asthma and raises both maternal and cord blood immunoglobulin E and invokes a Th2-dominated environment in utero (5 references)."
[Stress released norepinephrine from the sympathetic nervous system. Chiropractic adjustments have been proven reduce this release!]

"In summary, our research suggests that exposures, which modify microbial load during pregnancy, may increase a child's risk of developing allergic disease."

"Some of these exposures, particularly the use of antibiotics, are potentially avoidable."

WHAT WE ARE LOOKING AT:

1) Exposure to antibiotics in utero is associated with an increased risk of asthma, eczema and hay fever, in a dose-related manner.

2) The prevalence of allergic disease has increased dramatically in the developed world during the last 50 years, paralleling antibiotic use and reductions in early life microbial exposure.

3) Exposure to antibiotics early in life (first few years) increases the risk of developing allergic disease.

4) Because the immune system develops in utero, factors that modify microbial exposure at this time may have a long-term impact on the risk of developing allergic disease. One such factor is in utero exposure to antibiotics.

5) Maternal depression is also associated with an increased risk of developing all three allergic diseases. This could this be related to omega-3 essential fatty acid deficiency. Omega-3 deficiency is known to occur during pregnancy. Omega-3 deficiency is known to cause depressive illness. Omega-3 deficiency is known to increase the production of IgE, which in turn increases risk of asthma, eczema, and hay fever. Recall:

Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis
Journal of Affective Disorders:
Volume 69, Issues 1-3, May 2002, Pages 15-29

Joseph R. Hibbeln

Mothers selectively transfer docosahexaenoic acid (DHA) to their fetuses to support optimal neurological development during pregnancy.

Without sufficient dietary intake, mothers become depleted of DHA and may increase their risk of suffering major depressive symptoms in the postpartum period.

Higher concentrations of DHA in mothers' milk and greater seafood consumption both predicted lower prevalence rates of postpartum depression.

Mothers can become depleted of critical nutrients during pregnancy with adverse consequences for both mother and infant.

Mothers have a "higher risk of suffering postpartum depression when they become depleted of omega-3 essential fatty acids, in particular docosahexaenoic acid (DHA)."

"Maternal DHA status can be reduced by half during pregnancy and not fully restored at 26 weeks postpartum."

"An adequate supply of maternal DHA is necessary to support optimal neurological development of both fetus and infant."

"DHA is highly concentrated in synaptic neuronal membranes and has unique membrane biophysical properties critical to synaptic function."

DHA cannot be synthesized by either the mother or the fetus.

"DHA and or EPA depletion due to pregnancy may have adverse neuropsychiatric consequences for mothers."

"Inadequate intake of omega-3 fats is associated with major depression and other affective disorders."

(1)  DHA is necessary for the neurological development of both fetus and infant.

(2)  Inadequate intake of omega-3 fats is associated with major depression and other affective disorders, including bipolar disorders.

(3) The prevalence rates of major postpartum depressive symptoms is related to DHA omega-3 fatty acid consumption from fish.

Interesting we are unable to consume enough omega 3's in our diet due to high levels of environmental toxicity.  Even the FDA recommends only eating little fish as it is high in mercury from fish even from wild Alaska! Remember, the FDA allowed 55,000 people to DIE from the drug VIOXX before pulling it from the market....I'm sure if they are limited seafood consumption the situation is likely FAR WORSE then they are telling us.

For this reason I recommend a pharmaceutical grade fish oil.  The fish oil in our office is from Metagenics, the best around and is highly concentrated.  1 Teaspoon per day will give you the equivalent of 16 pills purchased at Costco and ours has a great taste!  

Even my flavor sensitive wife Alysha likes it!!!  Believe me thats saying something!  Have a BLESSED weekend folks!

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